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As Buddhist missions to Sri Lanka had to come by way of South India, the spread of Buddhism in Sri Lanka and South India in the 2nd century AD should be considered contemporary events, but it was King Asoka's son Mahinda who was responsible for the introduction of Buddhism in Tamil Nadu and Sri Lanka. Mahinda is said to have erected seven viharas at Kaveripattinum, the capital of Cola while he was on his way to Sri Lanka. According to Dr. Hikosaka, contrary to the general impression, Buddhism might have gone to Sri Lanka from Tamil Nadu by sea route, a route by which one can reach Sri Lanka easily. Since there existed very close cultural affinities between Sri Lanka and the Tamil country from time immemorial, the Buddhist activities in India could have easily influenced in some way or other the Buddhism of Sri Lanka, says Dr. Hikosaka. Even though it is believed that Buddha had visited this region, South India Andhra and Sri Lanka, according to historians, Buddhism began to make a strong impact on Tamil Nadu only in the 3rd century AD. During that period Buddhism had spread widely in Tamil Nadu and won the patronage of the rulers. The remains of a Buddhist monastery excavated at Kaveripattinum which could be assigned to the fourth century are believed to be the earliest archaeological relics of Buddhism in Tamil Nadu. The major urban centers of Kanchipuram, Kaveripattinam, Uragapura Uraiyur, and Madurai were not only centers of Buddhism, but these were also important centers of Pali learning. The other minor towns of Tamil country where Buddhism was active were Buddhamangalam, Sanghamangalam, Kumbakonam, Mayurapattanam, Alamkudipatti, Kuvam, Sanghamangai, Tiruppadirippuliyur, and so on.

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In 1980, a study published in Cancer Research established that formaldehyde was associated with nasal tumors in rats. Newer research, published inside a 2008 edition of the Bulletin of Environmental Contamination and Toxicology, found that individuals exposed to formaldehyde in a variety of indoor environments experienced cancer risks ten to one hundred times more than the acceptable chance of One in 1,000,000. Such research suggests that formaldehyde hurts and that aspartame, because it stops working into formaldehyde, is also damaging. Aside from associations with cancer, which are certainly alarming, aspartame consumption is associated with a myriad of health related ailments. As Michelle Hancock, author of the 2004 report published in Alive: Canadas Natural Health and Wellness Magazine, has noted when referring to aspartame, tens of thousands of complaints happen to be lodged, including reports of headaches, dizziness, epileptic like seizures, insomnia, vertigo, rashes, and anxiety p. 46.

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